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Study Details

Depression

Psychiatric disorders, Nervous system disorders, Depression
For whom: both gender, age 18 - 99
Study No.: CRUK36

Why is this study being conducted?

Clinical depression is common, debilitating and treatable; one in four people experience it during their lives. The majority of sufferers are treated in primary care and only half respond well to active treatment. Evidence suggests that folate may be a useful adjunct to antidepressant treatment: 1) patients with depression often have a functional folate deficiency; 2) the severity of such deficiency, indicated by elevated homocysteine, correlates with depression severity, 3) low folate is associated with poor antidepressant response, and 4) folate is required for the synthesis of neurotransmitters implicated in the pathogenesis and treatment of depression.

This study should determine wether giving folic acid to people with depression will help their antidepressants work better. If folate does help antidepressants to work better, then it will provide a safe, simple and cheap way of improving the treatment of depression.

What are the main eligibility criteria?

Inclusion Criteria:

  • Only patients aged 18 or over
  • ICD-10 diagnosis of moderate to severe depression

Exclusion Criteria:

Patients will be excluded from the study if they:

  • are folate deficient
  • are B12 deficient
  • have knowingly taken supplements containing folic acid within 2 months
  • suffer from psychosis
  • are taking anticonvulsants
  • are taking lithium

Important

If you are interested in participating in a clinical trial, please register and you will be contacted by the study coordinator or person involved with the specific trial you are interested in.

  • Prior to your participation a physician will inform you about the process in detail and examine if you are eligible to take part in the study.
  • If you are to participate all medication will be free.
  • Of course you can terminate during the process any time.

References:

Trial information was taken from the following sites:

  • http://clinicaltrials.gov/ct2/show/NCT00514410
  • In ClinLife opinion the main facts were taken and centralized. ClinLife isn´t liable for defects or wrong translation.
  • Official Title: Folate Augmentation of Treatment - Evaluation for Depression: a Randomised Controlled Trial

     

This study is being conducted at a number of locations.
If you decide to register, your contact details will be forwarded to the investigator site at the following location:
Bangor, Gwynedd, LL57 2PW

You can choose an alternate, more convenient location, by selecting from one of the entries below:

Swansea, SA2 8PP
Wrexham, LL13 7YP