Medication

Histamine antagonists:

Antihistamines such as Diphenhydramine, Hydroxyzine and Cetirizine  ( H1- receptor antagonists) are taken on a regular basis  to protective effects, lessening or halting attacks.

The H2- receptor antagonists such as Cemitidine  and Ranitidine control symptoms either prophylactically  or by lessening symptoms during an attack.

When taken in combination H1- and H2- receptor antagonists have a synergistic effect which is more effective than either treatment alone.

Tricyclic antidepressants:

Tricyclic antidepressants such as Doxepin are also potent  H1- and H2- receptor antagonists and may have a role in therapy although side effects limit their use.

Corticosteroids:

During severe attacks Corticosteroids such as Prednisone are sometimes prescribed although extensive side effects are known.